Across TCGA pan-cancer cohorts, IGLV3-16 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGLV3-16’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGLV3-16 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGLV3-16 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, CCRCC, and COAD are the cancer types where IGLV3-16 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV3-16 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.626	.002	8	view →
CCRCC	All	All	+0.644	.002	4	view →
COAD	All	All	−1.211	.011	2	view →
LSCC	Male	All	−0.586	.020	2	view →
LUAD	All	All	−0.433	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGLV3-16 RNA expression & survival · all IGLV3-16 data types