IGLV3-13

Across TCGA pan-cancer cohorts, IGLV3-13 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGLV3-13 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV3-13 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLV3-13 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where IGLV3-13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.739	0.583	<.001	144	view →
UCEC	DFS	Quartile	III,IV	0.923	0.748	.001	88	view →
SKCM	OS	Median	III,IV	0.894	0.751	<.001	77	view →
BRCA	OS	Median	All	0.637	0.517	.001	66	view →
ACC	DFS	Tertile	II,III,IV	0.010	0.582	<.001	45	view →
THYM	OS	Tertile	III,IV	0.579	1.000	.005	36	view →
COAD	OS	Tertile	All	0.833	0.585	.010	30	view →
CESC	OS	Median	All	0.924	0.823	.001	28	view →
THCA	OS	Tertile	III,IV	0.927	1.000	.002	19	view →
CHOL	OS	Tertile	II,III,IV	0.024	0.601	.025	18	view →
PAAD	OS	Tertile	II,III,IV	0.707	0.447	.004	10	view →
LUAD	OS	Median	II,III,IV	0.681	0.490	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGLV3-13–HNSC (OS)

Open the HNSC breakdown →