Across TCGA pan-cancer cohorts, IGLV3-10 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IGLV3-10 data layer compared with 18 for mass-spec protein and 2 for mutation status.
The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IGLV3-10 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV3-10 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.
PDAC, GBM, and LUAD are the cancer types where IGLV3-10 mass-spec protein most reproducibly stratifies survival.
mass-spec protein survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.