Across TCGA patient cohorts, IGLV3-1 mutation is significantly associated with the RNA expression of many other genes, with 259 significant associations in total. DLBC shows the largest number of these associations.

The most reproducible IGLV3-1-associated genes across cancer lineages are MAP1LC3A, ATP11C, and SLC35A2. Each is linked with IGLV3-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV3-1-to-partner and partner-to-IGLV3-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-1→partner) and Y-score (partner→IGLV3-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	MAP1LC3A →	-1.023	-2.523	.001	.003	3	1
DLBC	ATP11C →	+0.831	+3.169	.001	.005	3	1
DLBC	SLC35A2 →	+0.593	+2.058	.002	.009	3	1
DLBC	TRADD →	-0.438	-2.523	.003	.003	3	1
DLBC	NME3 →	-0.827	-2.523	.001	.003	3	1
DLBC	SIPA1L3 →	+1.098	+3.169	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 259 associations by consensus.

Exploration

IGLV3-1 survival (RNA) · tumor vs normal (RNA) · all IGLV3-1 data types