Across TCGA patient cohorts, IGLV3-1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. DLBC shows the largest number of these associations.

The most reproducible IGLV3-1-associated genes across cancer lineages are lymphatic Endothelial cells, mv Endothelial cells, and pro B-cells. Each is linked with IGLV3-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV3-1-to-partner and partner-to-IGLV3-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-1→partner) and Y-score (partner→IGLV3-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	lymphatic Endothelial cells →	-0.020	-3.082	.027	.006	3	1
DLBC	mv Endothelial cells →	-0.038	-3.321	.002	.002	3	1
DLBC	pro B-cells →	+0.205	+2.646	<.001	.001	3	1
DLBC	CD4+ naive T-cells →	-0.060	-2.758	.037	.014	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

IGLV3-1 survival (RNA) · tumor vs normal (RNA) · all IGLV3-1 data types