IGLV2-8

Across TCGA pan-cancer cohorts, IGLV2-8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGLV2-8 data layer compared with 21 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGLV2-8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV2-8 expression acts as an unfavorable survival marker.

COAD and SKCM are the cancer types where IGLV2-8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.168	0.806	.002	24	view →
SKCM	DFS	Median	II,III,IV	0.087	0.708	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGLV2-8–COAD (OS)

Open the COAD breakdown →