IGLV2-8

Across TCGA pan-cancer cohorts, IGLV2-8 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IGLV2-8 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGLV2-8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV2-8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

UCEC, LUAD, and COAD are the cancer types where IGLV2-8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.781	1.000	.001	56	view →
LUAD	OS	Median	All	0.920	1.000	.001	32	view →
COAD	DFS	Median	II,III,IV	0.904	1.000	.018	18	view →
PDAC	DFS	Quartile	All	0.876	0.721	.003	18	view →
CCRCC	DFS	Quartile	All	0.894	0.630	.009	17	view →
HNSC	OS	Tertile	II,III,IV	0.614	0.851	.021	7	view →
GBM	DFS	Median	All	0.426	0.221	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGLV2-8–UCEC (OS)

Open the UCEC breakdown →