IGLV2-5

Across TCGA pan-cancer cohorts, IGLV2-5 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated IGLV2-5 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV2-5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV2-5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where IGLV2-5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.673	0.535	<.001	144	view →
UVM	DFS	Tertile	All	0.173	0.761	<.001	99	view →
SKCM	DFS	Median	All	0.668	0.568	.003	80	view →
CESC	OS	Tertile	All	0.848	0.690	.003	56	view →
LUAD	DFS	Quartile	III,IV	0.921	0.384	.001	47	view →
ACC	DFS	Tertile	IV	0.010	0.383	<.001	45	view →
KIRC	DFS	Tertile	All	0.437	0.693	.001	37	view →
BRCA	OS	Median	II,III,IV	0.976	0.938	.005	34	view →
MESO	OS	Tertile	III,IV	0.732	0.461	.004	31	view →
COAD	DFS	Quartile	III,IV	0.757	0.387	.017	25	view →
CHOL	DFS	Tertile	All	0.830	0.228	.026	24	view →
PAAD	DFS	Quartile	II,III,IV	0.549	0.310	<.001	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

IGLV2-5–HNSC (DFS)

Open the HNSC breakdown →