IGLV2-34

Across TCGA pan-cancer cohorts, IGLV2-34 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGLV2-34 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV2-34 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLV2-34 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where IGLV2-34 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.764	0.603	<.001	144	view →
SKCM	OS	Median	All	0.417	0.274	<.001	78	view →
UVM	OS	Tertile	All	0.298	0.721	.004	63	view →
BRCA	DFS	Tertile	All	0.652	0.483	.001	63	view →
UCEC	OS	Tertile	III,IV	0.744	0.372	.001	60	view →
COAD	DFS	Tertile	III,IV	0.747	0.290	.002	50	view →
CESC	OS	Median	II,III,IV	0.850	0.649	.003	48	view →
READ	DFS	Median	IV	0.845	0.344	<.001	34	view →
GBM	OS	Tertile	All	0.119	0.448	<.001	30	view →
MESO	OS	Tertile	III,IV	0.724	0.443	.003	30	view →
LUAD	DFS	Quartile	III,IV	0.743	0.257	.005	29	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGLV2-34–HNSC (OS)

Open the HNSC breakdown →