Across TCGA patient cohorts, IGLV2-33 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,940 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGLV2-33-associated GO terms across cancer lineages are Complement activation, classical pathway, B cell mediated immunity, and Humoral immune response mediated by circulating immunoglobulin. Each is linked with IGLV2-33 in more than 27 cancer types. Because this analysis shows association rather than direction, both IGLV2-33-to-partner and partner-to-IGLV2-33 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV2-33→partner) and Y-score (partner→IGLV2-33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Complement activation, classical pathway →	+0.184	+0.767	<.001	<.001	3	28
ESCA	B cell mediated immunity →	+0.094	+0.581	<.001	<.001	3	28
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.153	+0.760	<.001	<.001	3	27
ESCA	Interleukin-6 production →	+0.047	+0.601	<.001	<.001	3	27
CHOL	Antigen receptor-mediated signaling pathway →	+0.074	+1.189	<.001	.003	3	27
CHOL	B cell receptor signaling pathway →	+0.093	+1.095	<.001	.006	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,940 associations by consensus.

Exploration

IGLV2-33 survival (RNA) · tumor vs normal (RNA) · all IGLV2-33 data types