Across TCGA patient cohorts, IGLV2-33 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGLV2-33-associated genes across cancer lineages are RPS28P1, RN7SL126P, and MIR6076. Each is linked with IGLV2-33 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV2-33-to-partner and partner-to-IGLV2-33 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV2-33→partner) and Y-score (partner→IGLV2-33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPS28P1 →	+0.500	+6.027	<.001	.002	3	1
SKCM	RN7SL126P →	+0.093	+2.978	.005	.007	3	1
SKCM	MIR6076 →	+0.492	+4.730	<.001	<.001	3	1
SKCM	UGT1A13P →	+0.033	+4.212	<.001	.007	3	1
SKCM	OR52X1P →	+0.035	+4.097	<.001	<.001	3	1
SKCM	LINC00851 →	+0.073	+3.300	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration

IGLV2-33 survival (RNA) · tumor vs normal (RNA) · all IGLV2-33 data types