Across TCGA patient cohorts, IGLV2-14 RNA expression is significantly associated with the mutation status of many other genes, with 9,806 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV2-14-associated genes across cancer lineages are TP53, TTN, and TRPC5. Each is linked with IGLV2-14 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGLV2-14-to-partner and partner-to-IGLV2-14 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV2-14→partner) and Y-score (partner→IGLV2-14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TP53 →	-1.657	-1.011	<.001	<.001	3	5
LIHC	TTN →	-1.000	-0.919	.001	.001	2	4
UCEC	TRPC5 →	+1.544	+1.564	<.001	<.001	3	3
UCEC	BRAF →	+2.736	+1.833	<.001	.002	3	2
PRAD	RYR2 →	-3.081	-1.490	<.001	.002	3	2
BLCA	KRAS →	-2.800	-2.131	.003	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,806 associations by consensus.

Exploration

IGLV2-14 survival (RNA) · tumor vs normal (RNA) · all IGLV2-14 data types