Across TCGA patient cohorts, IGLV2-11 protein abundance is significantly associated with the RNA expression of many other genes, with 9,778 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGLV2-11-associated genes across cancer lineages are LILRB5, IGHV3-7, and IGHV4-59. Each is linked with IGLV2-11 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGLV2-11-to-partner and partner-to-IGLV2-11 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV2-11→partner) and Y-score (partner→IGLV2-11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LILRB5 →	+0.742	+0.744	<.001	<.001	3	6
OV	IGHV3-7 →	+2.551	+1.322	.008	<.001	3	6
OV	IGHV4-59 →	+2.785	+0.896	<.001	<.001	3	6
LSCC	CPNE5 →	+0.734	+1.006	<.001	<.001	3	5
BRCA	LAX1 →	+0.914	+0.747	<.001	<.001	3	5
OV	IGKC →	+3.556	+1.438	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,778 associations by consensus.

Exploration

IGLV2-11 survival (RNA) · tumor vs normal (RNA) · all IGLV2-11 data types