Across TCGA patient cohorts, IGLV10-54 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV10-54-associated genes across cancer lineages are SELENOTP2, RNA5SP412, and MIR7845. Each is linked with IGLV10-54 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV10-54-to-partner and partner-to-IGLV10-54 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV10-54→partner) and Y-score (partner→IGLV10-54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SELENOTP2 →	+0.295	+4.233	<.001	.009	3	1
UCEC	RNA5SP412 →	+1.862	+4.552	<.001	.005	3	1
UCEC	MIR7845 →	+1.133	+4.423	<.001	.006	3	1
LUSC	RNU6-888P →	+0.377	+4.984	.001	.009	3	1
LUSC	TRAJ54 →	+0.572	+5.093	.001	.008	3	1
LUSC	RN7SL822P →	+0.155	+5.548	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

IGLV10-54 survival (RNA) · tumor vs normal (RNA) · all IGLV10-54 data types