Across TCGA patient cohorts, IGLV1-51 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV1-51-associated genes across cancer lineages are RNU4-65P, RNVU1-28, and LINC01727. Each is linked with IGLV1-51 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV1-51-to-partner and partner-to-IGLV1-51 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV1-51→partner) and Y-score (partner→IGLV1-51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-65P →	+0.325	+4.453	<.001	<.001	3	2
UCEC	RNVU1-28 →	+1.157	+3.442	<.001	.001	3	1
UCEC	LINC01727 →	+0.082	+2.773	.007	.008	3	1
LUSC	RNU6-560P →	+0.611	+6.309	<.001	.001	3	1
LUSC	UBE2V1P9 →	+0.453	+5.273	<.001	.006	3	1
LUSC	MIR4314 →	+0.423	+5.151	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

IGLV1-51 survival (RNA) · tumor vs normal (RNA) · all IGLV1-51 data types