Across TCGA pan-cancer cohorts, IGLV1-47 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGLV1-47 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV1-47 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV1-47 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where IGLV1-47 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.965	0.684	.022	22	view →
LUAD	OS	Tertile	All	0.889	1.000	.022	7	view →
PDAC	DFS	Quartile	III,IV	0.151	0.566	.035	4	view →
UCEC	DFS	Tertile	All	0.854	0.982	.044	2	view →
GBM	DFS	Tertile	All	0.614	0.806	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGLV1-47 tumor-vs-normal RNA expression · all IGLV1-47 data types