Across TCGA pan-cancer cohorts, IGLV1-44 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGLV1-44 data layer compared with 2 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV1-44 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV1-44 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGLV1-44 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.751	0.639	<.001	145	view →
SKCM	OS	Median	All	0.427	0.258	<.001	96	view →
BRCA	DFS	Tertile	All	0.969	0.920	<.001	79	view →
LIHC	DFS	Tertile	All	0.596	0.421	<.001	51	view →
UCEC	OS	Median	III,IV	0.722	0.398	.002	40	view →
OV	DFS	Quartile	II,III,IV	0.440	0.311	.003	28	view →
SARC	DFS	Median	All	0.637	0.431	.003	28	view →
COAD	DFS	Tertile	III,IV	0.725	0.362	.024	24	view →
KIRP	OS	Median	All	0.580	0.892	.003	22	view →
GBM	OS	Quartile	All	0.315	0.504	.001	18	view →
KIRC	DFS	Tertile	All	0.474	0.717	.009	15	view →
CESC	DFS	Quartile	All	0.848	0.661	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: IGLV1-44 tumor-vs-normal RNA expression · all IGLV1-44 data types