Across TCGA patient cohorts, IGLV1-40 protein abundance is significantly associated with the RNA expression of many other genes, with 10,003 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGLV1-40-associated genes across cancer lineages are P2RX1, IRF4, and NCF1B. Each is linked with IGLV1-40 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGLV1-40-to-partner and partner-to-IGLV1-40 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV1-40→partner) and Y-score (partner→IGLV1-40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	P2RX1 →	+0.725	+0.709	<.001	<.001	3	7
UCEC	IRF4 →	+1.208	+1.159	<.001	<.001	3	7
COAD	NCF1B →	+0.775	+0.704	<.001	<.001	3	7
BRCA	IGLV7-46 →	+2.292	+0.778	<.001	<.001	3	7
OV	IGLC3 →	+3.285	+0.762	<.001	<.001	3	7
OV	IGHV1-18 →	+3.672	+1.221	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,003 associations by consensus.

Exploration

IGLV1-40 survival (RNA) · tumor vs normal (RNA) · all IGLV1-40 data types