Across TCGA patient cohorts, IGLV1-40 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV1-40-associated genes across cancer lineages are MIR6133, MIR6854, and MIRLET7C. Each is linked with IGLV1-40 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV1-40-to-partner and partner-to-IGLV1-40 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV1-40→partner) and Y-score (partner→IGLV1-40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6133 →	+0.555	+3.982	<.001	.003	3	1
UCEC	MIR6854 →	+0.373	+4.582	<.001	.005	3	1
UCEC	MIRLET7C →	+0.608	+3.599	<.001	.007	3	1
UCEC	RNU6-582P →	+0.444	+5.245	<.001	.002	3	1
UCEC	RNA5SP223 →	+0.352	+4.582	<.001	.005	3	1
UCEC	RNU6-444P →	+0.767	+4.470	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

IGLV1-40 survival (RNA) · tumor vs normal (RNA) · all IGLV1-40 data types