IGLON5

Across TCGA cell cohorts, IGLON5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. CNS shows the largest number of these associations.

The most reproducible IGLON5-associated genes across cancer lineages are PRSS58, ASPN, and C1QA. Each is linked with IGLON5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLON5-to-partner and partner-to-IGLON5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by IGLON5-low versus IGLON5-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLON5→partner) and Y-score (partner→IGLON5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.050	+3.426	<.001	.007	3	1
LARGE_INTESTINE	C1QA →	+0.115	+2.925	.001	.007	3	1
CNS	OR10G7 →	+0.013	+6.357	<.001	<.001	3	1
CNS	SCGB1C1 →	+0.284	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PRSS58 by IGLON5 expression — PANCREAS

Explore this box plot interactively →