IGLL5

Across TCGA pan-cancer cohorts, IGLL5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGLL5 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGLL5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGLL5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

UCEC, COAD, and HNSC are the cancer types where IGLL5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.399	0.919	.010	44	view →
COAD	DFS	Median	All	0.917	1.000	.011	36	view →
HNSC	DFS	Quartile	All	0.863	0.698	.014	17	view →
LUAD	DFS	Median	All	1.000	0.638	.001	14	view →
CCRCC	DFS	Median	All	0.841	0.628	.024	3	view →
PDAC	DFS	Quartile	All	0.849	0.775	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IGLL5–UCEC (DFS)

Open the UCEC breakdown →