IGLL5

Across TCGA cell cohorts, IGLL5 mutation is significantly associated with the RNA expression of many other genes, with 475 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IGLL5-associated genes across cancer lineages are R3HDML, HBZ, and EPB42. Each is linked with IGLL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLL5-to-partner and partner-to-IGLL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by IGLL5-low versus IGLL5-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLL5→partner) and Y-score (partner→IGLL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	R3HDML →	+0.037	+3.285	.001	.009	3	1
BLOOD_Myeloma	HBZ →	+0.033	+3.716	.001	.005	3	1
BLOOD_Myeloma	EPB42 →	+0.044	+3.716	<.001	.005	3	1
BLOOD_Myeloma	CATSPER4 →	+0.013	+3.285	<.001	.009	3	1
BLOOD_Lymphoma	SLC35E4 →	-0.813	-3.459	.004	.002	3	1
BLOOD_Lymphoma	MCAT →	+0.754	+2.321	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 475 associations by consensus.

R3HDML by IGLL5 expression — BLOOD_Myeloma

Explore this box plot interactively →