IGLL1

Across TCGA pan-cancer cohorts, IGLL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGLL1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where IGLL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.973	0.166	.010	23	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	9	view →
UCEC	OS	Median	All	0.911	0.987	.038	2	view →
GBM	OS	Tertile	All	0.265	0.494	.026	2	view →
CCRCC	DFS	Quartile	II,III,IV	0.337	1.000	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGLL1–HNSC (DFS)

Open the HNSC breakdown →