Across TCGA pan-cancer cohorts, IGLJ7 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGLJ7’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where IGLJ7 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLJ7 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.
STAD and LUAD are the cancer types where IGLJ7 tumor–normal differential expression is most reproducible.