Across TCGA pan-cancer cohorts, IGKV6D-41 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGKV6D-41 data layer compared with 14 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGKV6D-41 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV6D-41 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

COAD, LIHC, and LUAD are the cancer types where IGKV6D-41 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.028	0.668	<.001	18	view →
LIHC	OS	Median	All	0.015	0.784	<.001	12	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
LUSC	DFS	Median	All	0.864	0.381	.017	6	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGKV6D-41 tumor-vs-normal RNA expression · all IGKV6D-41 data types