Across TCGA pan-cancer cohorts, IGKV6D-41 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGKV6D-41 data layer compared with 14 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IGKV6D-41 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV6D-41 expression acts as an unfavorable survival marker.

LSCC are the cancer types where IGKV6D-41 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.128	0.859	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: IGKV6D-41 tumor-vs-normal RNA expression · all IGKV6D-41 data types