Across TCGA pan-cancer cohorts, IGKV5-2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV5-2 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IGKV5-2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV5-2 expression acts as an unfavorable survival marker.

LSCC and LUAD are the cancer types where IGKV5-2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.490	0.969	.040	2	view →
LUAD	OS	Median	II,III,IV	0.495	0.762	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IGKV5-2 tumor-vs-normal RNA expression · all IGKV5-2 data types