Across TCGA patient cohorts, IGKV5-2 protein abundance is significantly associated with the RNA expression of many other genes, with 783 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGKV5-2-associated genes across cancer lineages are GPR84, EXOC1, and LINC00160. Each is linked with IGKV5-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV5-2-to-partner and partner-to-IGKV5-2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV5-2→partner) and Y-score (partner→IGKV5-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPR84 →	+2.045	+1.164	.001	.002	3	2
LUAD	EXOC1 →	-0.406	-0.903	<.001	<.001	3	2
GBM	LINC00160 →	+0.511	+0.686	<.001	<.001	3	2
UCEC	MIOX →	+3.300	+1.164	.002	.002	3	1
UCEC	TLR8 →	+1.640	+1.164	.007	.002	3	1
UCEC	MAP4K1 →	+1.979	+1.149	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 783 associations by consensus.

Exploration

IGKV5-2 survival (RNA) · tumor vs normal (RNA) · all IGKV5-2 data types