Across TCGA patient cohorts, IGKV5-2 protein abundance is significantly associated with the protein abundance of many other proteins, with 1,868 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGKV5-2-associated proteins across cancer lineages are ANKRD11_S505, IGKV3-20, and IGHV3OR15-7. Each is linked with IGKV5-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV5-2-to-partner and partner-to-IGKV5-2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV5-2→partner) and Y-score (partner→IGKV5-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANKRD11_S505 →	-1.242	-1.039	<.001	<.001	3	2
GBM	IGKV3-20 →	+1.651	+0.762	<.001	.002	3	2
UCEC	IGHV3OR15-7 →	+2.040	+1.164	.003	.002	2	2
UCEC	ARAP1 →	+0.804	+1.164	.009	.002	2	2
LSCC	SP1_T49 →	-0.626	-0.846	<.001	<.001	3	1
LSCC	SPHK2 →	+0.246	+1.072	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,868 associations by consensus.

Exploration

IGKV5-2 survival (RNA) · tumor vs normal (RNA) · all IGKV5-2 data types