Across TCGA pan-cancer cohorts, IGKV4-1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV4-1 data layer compared with 26 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher IGKV4-1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV4-1 expression acts as an unfavorable survival marker.

BRCA and SKCM are the cancer types where IGKV4-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.131	0.924	<.001	36	view →
SKCM	DFS	Median	All	0.058	0.757	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IGKV4-1 tumor-vs-normal RNA expression · all IGKV4-1 data types