Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts
Across TCGA patient cohorts, IGKV4-1 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. SKCM shows the largest number of these associations.
The most reproducible IGKV4-1-associated genes across cancer lineages are OR2B3, PTP4A1P4, and OR10AE1P. Each is linked with IGKV4-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV4-1-to-partner and partner-to-IGKV4-1 results are reported.
Each partner links to its own Q-omics profile.
mutation associated genes by consensus
Ranked by combined sampling and lineage consensus. X-score (IGKV4-1→partner) and Y-score (partner→IGKV4-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.