Across TCGA pan-cancer cohorts, IGKV3D-7 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV3D-7 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3D-7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV3D-7 expression acts as an unfavorable survival marker.

HNSC and LIHC are the cancer types where IGKV3D-7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.013	0.746	<.001	24	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IGKV3D-7 tumor-vs-normal RNA expression · all IGKV3D-7 data types