Across TCGA patient cohorts, IGKV3D-7 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,482 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV3D-7-associated proteins across cancer lineages are MZB1, IRF4, and TXNDC5. Each is linked with IGKV3D-7 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGKV3D-7-to-partner and partner-to-IGKV3D-7 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3D-7→partner) and Y-score (partner→IGKV3D-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MZB1 →	+1.137	+0.449	.001	.006	3	8
BRCA	IRF4 →	+1.072	+0.734	<.001	<.001	3	7
LSCC	TXNDC5 →	+0.659	+1.112	<.001	<.001	3	6
LSCC	UBE2J1 →	+0.660	+1.106	<.001	<.001	3	6
LSCC	CD38 →	+0.984	+1.337	<.001	<.001	3	6
BRCA	CD48 →	+0.787	+0.702	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,482 associations by consensus.

Exploration

IGKV3D-7 survival (RNA) · tumor vs normal (RNA) · all IGKV3D-7 data types