Across TCGA patient cohorts, IGKV3D-7 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV3D-7-associated genes across cancer lineages are RNU6-747P, RNU7-51P, and RPL23AP68. Each is linked with IGKV3D-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV3D-7-to-partner and partner-to-IGKV3D-7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3D-7→partner) and Y-score (partner→IGKV3D-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-747P →	+0.273	+7.954	<.001	.008	3	1
HNSC	RNU7-51P →	+0.677	+7.954	<.001	.008	3	1
UCEC	RPL23AP68 →	+0.353	+5.133	<.001	.008	3	1
UCEC	FABP5P6 →	+0.255	+4.982	.006	.009	3	1
UCEC	RNU6-1101P →	+1.120	+4.982	<.001	.009	3	1
UCEC	RNU6-1150P →	+0.661	+6.226	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

IGKV3D-7 survival (RNA) · tumor vs normal (RNA) · all IGKV3D-7 data types