IGKV3D-31

Across TCGA pan-cancer cohorts, IGKV3D-31 RNA is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated IGKV3D-31 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher IGKV3D-31 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV3D-31 expression acts as an unfavorable survival marker.

LIHC, STAD, and SKCM are the cancer types where IGKV3D-31 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	II,III,IV	0.042	0.716	<.001	54	view →
STAD	DFS	Tertile	III,IV	0.222	0.509	.015	18	view →
SKCM	OS	Tertile	All	0.757	0.877	.020	15	view →
LUAD	OS	Tertile	II,III,IV	0.503	0.694	.014	9	view →
LUSC	OS	Tertile	II,III,IV	0.158	0.544	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGKV3D-31–LIHC (OS)

Open the LIHC breakdown →