Across TCGA patient cohorts, IGKV3D-15 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV3D-15-associated genes across cancer lineages are MIR320C2, MIR670, and RNU6-1078P. Each is linked with IGKV3D-15 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV3D-15-to-partner and partner-to-IGKV3D-15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3D-15→partner) and Y-score (partner→IGKV3D-15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR320C2 →	+0.776	+5.157	<.001	.007	3	2
SKCM	MIR670 →	+0.275	+4.624	<.001	.005	3	2
HNSC	RNU6-1078P →	+0.278	+7.954	<.001	.008	3	1
HNSC	RNU6-159P →	+0.274	+7.954	<.001	.008	3	1
SKCM	RNU7-54P →	+0.417	+4.771	<.001	<.001	3	1
SKCM	SCGB1D5P →	+0.090	+5.219	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

IGKV3D-15 survival (RNA) · tumor vs normal (RNA) · all IGKV3D-15 data types