IGKV3-7

Across TCGA pan-cancer cohorts, IGKV3-7 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGKV3-7 data layer compared with 22 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher IGKV3-7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV3-7 expression acts as an unfavorable survival marker.

ESCA, LIHC, and LUSC are the cancer types where IGKV3-7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	18	view →
LIHC	OS	Median	All	0.042	0.775	<.001	12	view →
LUSC	OS	Median	All	0.146	0.409	.029	8	view →
PRAD	DFS	Median	All	0.200	0.775	.013	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGKV3-7–ESCA (OS)

Open the ESCA breakdown →