IGKV3-7

Across TCGA pan-cancer cohorts, IGKV3-7 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated IGKV3-7 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGKV3-7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV3-7 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and OV show a favorable association.

COAD, UCEC, and CCRCC are the cancer types where IGKV3-7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.920	1.000	.014	66	view →
UCEC	OS	Median	III,IV	0.287	1.000	.004	40	view →
CCRCC	DFS	Tertile	All	0.810	0.498	.011	8	view →
OV	DFS	Median	All	1.000	0.686	.026	4	view →
PDAC	OS	Median	IV	0.911	0.540	.049	3	view →
LUAD	DFS	Median	All	0.813	0.679	.041	2	view →
HNSC	OS	Tertile	II,III,IV	0.946	1.000	.038	2	view →
LSCC	OS	Tertile	All	0.957	0.809	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IGKV3-7–COAD (DFS)

Open the COAD breakdown →