IGKV3-15

Across TCGA pan-cancer cohorts, IGKV3-15 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV3-15 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IGKV3-15 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV3-15 expression acts as an unfavorable survival marker.

LUSC and HNSC are the cancer types where IGKV3-15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.348	0.678	.014	10	view →
HNSC	OS	Median	All	0.151	0.660	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGKV3-15–LUSC (OS)

Open the LUSC breakdown →