IGKV2OR2-7D

Across TCGA pan-cancer cohorts, IGKV2OR2-7D RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated IGKV2OR2-7D data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2OR2-7D RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV2OR2-7D expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, ESCA, and BLCA are the cancer types where IGKV2OR2-7D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.795	0.624	.002	81	view →
ESCA	OS	Tertile	III,IV	0.319	0.614	.001	72	view →
BLCA	OS	Tertile	All	0.816	0.528	.010	36	view →
UCS	OS	Tertile	All	0.247	0.694	.016	36	view →
CESC	OS	Tertile	All	0.908	0.770	.018	24	view →
COAD	DFS	Tertile	All	0.936	0.660	.015	15	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	9	view →
LUAD	OS	Quartile	II,III,IV	0.101	0.325	.006	8	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IGKV2OR2-7D–HNSC (DFS)

Open the HNSC breakdown →