IGKV2D-36

Across TCGA pan-cancer cohorts, IGKV2D-36 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGKV2D-36 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher IGKV2D-36 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2D-36 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

READ, OV, and GBM are the cancer types where IGKV2D-36 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	All	0.188	0.829	<.001	99	view →
OV	DFS	Tertile	All	0.172	0.542	.009	54	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	36	view →
LAML	DFS	Tertile	All	0.028	0.572	<.001	36	view →
ESCA	OS	Tertile	All	0.211	0.876	.028	18	view →
KIRC	DFS	Tertile	IV	0.037	0.632	<.001	18	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
LUSC	OS	Tertile	III,IV	0.214	0.539	.045	9	view →
HNSC	OS	Tertile	All	0.870	0.671	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGKV2D-36–READ (OS)

Open the READ breakdown →