IGKV2D-29

Across TCGA pan-cancer cohorts, IGKV2D-29 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGKV2D-29 data layer compared with 20 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IGKV2D-29 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2D-29 expression acts as an unfavorable survival marker.

KIRC, SKCM, and KIRP are the cancer types where IGKV2D-29 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.062	0.874	<.001	36	view →
SKCM	DFS	Median	All	0.217	0.730	.001	15	view →
KIRP	OS	Median	All	0.118	0.688	.007	6	view →
HNSC	OS	Median	All	0.187	0.685	.042	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LGG	OS	Median	All	0.415	0.811	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IGKV2D-29–KIRC (OS)

Open the KIRC breakdown →