IGKV2D-29

Across TCGA pan-cancer cohorts, IGKV2D-29 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IGKV2D-29 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGKV2D-29 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV2D-29 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where IGKV2D-29 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.766	1.000	.001	32	view →
LUAD	DFS	Tertile	All	0.777	0.981	.001	20	view →
PDAC	DFS	Quartile	III,IV	0.154	0.719	.005	9	view →
CCRCC	OS	Median	All	1.000	0.911	.023	8	view →
GBM	DFS	Median	All	0.506	0.253	.006	3	view →
HNSC	OS	Median	IV	0.838	0.627	.031	2	view →
LSCC	OS	Median	All	0.914	0.834	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGKV2D-29–UCEC (DFS)

Open the UCEC breakdown →