IGKV2D-28

Across TCGA pan-cancer cohorts, IGKV2D-28 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGKV2D-28 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGKV2D-28 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2D-28 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD are the cancer types where IGKV2D-28 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.883	0.302	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

IGKV2D-28–LUAD (OS)

Open the LUAD breakdown →