Across TCGA patient cohorts, IGKV1OR2-3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,927 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1OR2-3-associated GO terms across cancer lineages are B cell mediated immunity, Humoral immune response mediated by circulating immunoglobulin, and Antigen receptor-mediated signaling pathway. Each is linked with IGKV1OR2-3 in more than 26 cancer types. Because this analysis shows association rather than direction, both IGKV1OR2-3-to-partner and partner-to-IGKV1OR2-3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1OR2-3→partner) and Y-score (partner→IGKV1OR2-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.097	+1.217	<.001	<.001	3	27
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.157	+1.068	<.001	<.001	3	27
SKCM	Antigen receptor-mediated signaling pathway →	+0.058	+0.783	<.001	<.001	3	27
SKCM	B cell receptor signaling pathway →	+0.080	+0.788	<.001	<.001	3	27
THCA	Complement activation, classical pathway →	+0.189	+1.087	<.001	<.001	3	27
THCA	Antimicrobial humoral response →	+0.114	+1.133	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,927 associations by consensus.

Exploration

IGKV1OR2-3 survival (RNA) · tumor vs normal (RNA) · all IGKV1OR2-3 data types