IGKV1OR2-11

Across TCGA pan-cancer cohorts, IGKV1OR2-11 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV1OR2-11 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR2-11 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV1OR2-11 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and OV are the cancer types where IGKV1OR2-11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.807	0.697	<.001	144	view →
SKCM	OS	Median	All	0.460	0.279	<.001	74	view →
OV	DFS	Tertile	III,IV	0.213	0.131	.004	54	view →
CHOL	DFS	Tertile	All	0.830	0.243	<.001	51	view →
KIRP	OS	Tertile	All	0.426	0.771	<.001	40	view →
BRCA	OS	Median	All	0.975	0.950	.002	29	view →
CESC	DFS	Quartile	All	0.843	0.683	.006	24	view →
LIHC	DFS	Tertile	II,III,IV	0.694	0.390	.011	21	view →
PAAD	OS	Quartile	II,III,IV	0.720	0.444	.005	20	view →
GBM	OS	Tertile	All	0.058	0.416	<.001	18	view →
DLBC	DFS	Median	III,IV	1.000	0.328	.003	17	view →
BLCA	DFS	Tertile	All	0.712	0.518	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV1OR2-11–HNSC (OS)

Open the HNSC breakdown →