IGKV1D-8

Across TCGA pan-cancer cohorts, IGKV1D-8 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGKV1D-8 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGKV1D-8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1D-8 expression acts as an unfavorable survival marker.

COAD are the cancer types where IGKV1D-8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.056	0.783	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

IGKV1D-8–COAD (OS)

Open the COAD breakdown →