IGKV1D-8

Across TCGA pan-cancer cohorts, IGKV1D-8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGKV1D-8 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGKV1D-8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV1D-8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where IGKV1D-8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.823	0.986	<.001	48	view →
CCRCC	DFS	Median	III,IV	0.755	0.208	.025	11	view →
GBM	DFS	Median	All	0.856	0.655	.022	7	view →
LSCC	DFS	Tertile	II,III,IV	0.871	1.000	.014	6	view →
PDAC	DFS	Median	All	0.220	0.598	.027	5	view →
HNSC	OS	Quartile	IV	1.000	0.686	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IGKV1D-8–LUAD (DFS)

Open the LUAD breakdown →