Across TCGA patient cohorts, IGKV1D-42 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,049 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1D-42-associated GO terms across cancer lineages are Antibacterial humoral response, Humoral immune response mediated by circulating immunoglobulin, and Complement activation. Each is linked with IGKV1D-42 in more than 29 cancer types. Because this analysis shows association rather than direction, both IGKV1D-42-to-partner and partner-to-IGKV1D-42 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-42→partner) and Y-score (partner→IGKV1D-42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Antibacterial humoral response →	+0.164	+1.552	<.001	<.001	3	30
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.162	+1.427	<.001	<.001	3	30
THCA	Complement activation →	+0.154	+1.425	<.001	<.001	3	29
THCA	Complement activation, classical pathway →	+0.198	+1.450	<.001	<.001	3	29
CHOL	B cell receptor signaling pathway →	+0.089	+1.151	<.001	<.001	3	29
CHOL	Positive regulation of respiratory burst →	+0.140	+1.151	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,049 associations by consensus.

Exploration

IGKV1D-42 survival (RNA) · tumor vs normal (RNA) · all IGKV1D-42 data types