Across TCGA patient cohorts, IGKV1D-42 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV1D-42-associated genes across cancer lineages are NF-kB-p65_pS536, FOXO3a, and INPP4B. Each is linked with IGKV1D-42 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-42-to-partner and partner-to-IGKV1D-42 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-42→partner) and Y-score (partner→IGKV1D-42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	NF-kB-p65_pS536 →	-0.403	-3.000	.021	.033	3	1
UCEC	FOXO3a →	+0.121	+2.820	.008	.035	3	1
UCEC	INPP4B →	-0.340	-3.584	.019	.002	3	1
UCEC	JNK2 →	+0.265	+2.700	.003	.006	3	1
UCEC	mTOR_pS2448 →	-0.156	-2.000	.020	.032	3	1
UCEC	Notch1 →	+0.204	+2.700	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

IGKV1D-42 survival (RNA) · tumor vs normal (RNA) · all IGKV1D-42 data types